Endocrine Abstracts

Introduction: Graves’ disease and toxic multinodular goiter are known to have different etiologies and pathogenesis, which are not fully comprehended today. This study compares the protein profiles of Graves’ disease and toxic multinodular goiter patients’ thyroid samples using proteomics methods and investigates the role of differentiating proteins in the pathogenesis of these diseases.Methods and Design: Difference Gel Electrophoresis (D...

Objective: Various effects of glucocorticoids occur in brown adipose tissue depending on their duration of action. As a result of exposure to glucocorticoids, thermogenesis and oxygen use in brown fat tissue are reduced in animal studies. In this study, we aimed to compare the levels of UCP1 (uncoupling protein 1), Irisin, BMP 7 (bone morpogenic protein), PRDM16, which are brown addipose tissue markers, between patients with Cushing’s disease and healthy controls<p c...

Background: Thyroid diseases are commonly encountered in the population though it is unanswered for whom screening tests are useful. We aimed to see the value of TSH screening and to find out comorbidities of any thyroid diseases among these patients who were diagnosed by screening.Method: All consecutive patients (n: 796) who admitted to outpatient Clinics of Internal Medicine, between 1 and 31 January 2007 were recruited in the study. Age, gende...

Objective: The measurement of epicardial adipose tissue (EAT) sonographically is reported to be related with both obesity and insulin resistance. Hepatic steatosis is one of the best known other coincidence with obesity. We aimed to evaluate the relationships between EAT thickness, hepatic steatosis and insulin resistance in obese patients.Methods: Obese 63 subjects were enrolled into the study. Local ethical committee approval was obtained. Patients wer...

IntroductionThe most common causes of pseudo Cushing syndrome are alcoholism, chronic kidney disease, neuropsychiatric diseases, pregnancy, uncontrolled diabetes, and drugs. We present a patient who was operated on suspected Cushing syndrome based on abnormal results in overnight dexamethasone suppression tests.Case presentationA 49-year-old female patient was referred to our clinic for reoperation due to per...

Objective: Even with advancements in diagnostic techniques, acromegaly continues to be diagnosed late. This study aimed to employ deep learning methods to automatically identify acromegaly disease from images of faces, hands, and feet to enhance the efficiency of disease detection.Design: Cross-sectionaly single-center study with deep learningMethods: The study included 71 acromegaly patients and 65 healthy controls. All patients h...

Pasireotide is a second-generation, multireceptor-targeted somatostatin receptor ligand and is approved for the treatment of patients with Cushing’s Didease (CD) for whom surgery has failed or is not an option. This retrospective single center study aims to report the efficacy, side effects and follow-up of the treatment with pasireotide alone or in combination with cabergoline in patients without remission after transsphenoidal surgery. Among 187 patients with CD, 15 pat...

Purpose: Asprosin is a novel glucogenic adipokine produced by the fibrillin 1 (FBN1) gene that is generated and released by white adipose tissue during fasting. Asprosin hormone has been shown to improve the sense of smell in wild-type mice by activating the OLFR734 receptor and decreasing the time it takes for them to discover hidden food. The purpose of this study was to determine the effects of asprosin on the sense of smell in female rats through the use of a hidden cookie...

This study was carried out to put the Diabetes Health Promotion Self-Care Scale for patients with Type 2 diabetes mellitus (DM) into use for nursing and medical literature. The sample of this methodological design research consisted of 620 patients diagnosed with type 2 DM. The data were collected with Personal Information Form and the Diabetes Health Promotion Self-Care Scale. In the validity and reliability stage of the scale, exploratory and confirmatory factor analyzes, an...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare, heritable syndrome characterized by a hyperparathyroidism, pituitary adenoma and pancreatic islet cells.Case: A 56-year-old male patient had a single parathyroid excised for primary hyperparathyroidism 10 years ago. He was further investigated due to hypoglycemia and a mass was found in the head of the pancreas on MRI. It was reported as neuroendocrine tumor and no recurrence was found i...